Lead Sponsor

AstraZeneca

Age

19 - 45 years

Sex

ALL

Healthy Volunteers

Yes

•Men and women ages 19 to 45 inclusive
•Healthy subjects as determined by no clinically significant deviation from normal in medical history, physical examination, electrocardiograms (ECGs), and clinical laboratory determinations
•Body Mass Index (BMI) of 18 to 32 kg/m2, inclusive. BMI = weight (kg)/ \[height (m)\]2

•Women of child-bearing potential (WOCBP) who are unwilling or unable to use acceptable barrier methods (condoms and spermicides) to avoid pregnancy for the entire study period and for up to 8 weeks after the last dose of investigational product
•Any significant acute or chronic medical illness
•Current or recent (within 3 months) gastrointestinal disease
•Any major surgery within 4 weeks of study drug administration
•History of allergy to Dipeptidyl peptidase 4 (DPP4) inhibitor or related compounds
•History of allergy or intolerance to metformin or other similar acting agents
•Prior exposure to saxagliptin
•Prior exposure to metformin within 3 months of study drug administration.
•Estimated creatinine clearance (Clcr) of \< 80ml/min using the Cockcroft Gault formula