Identifying Biomarkers for Lung Cancer Using Tissue Samples From Patients With Lung Cancer and From Healthy Participants

Inclusion Criteria

• •DISEASE CHARACTERISTICS:
• •Meets 1 of the following criteria:
• •* Known or previously diagnosed lung cancer
• •* Suspected lung cancer, including the following:
• •* Completely resected stage I lung cancer (with no evidence of metastatic disease) for which patient is at risk for developing secondary disease
• •* Suspected of having lung cancer due to clinical symptoms, such as positive sputum cytology, hemoptysis, unresolved pneumonia, persistent cough, and positive x-ray
• •* Healthy volunteer
• •PATIENT CHARACTERISTICS:
• •WBC ≥ 2,000/mm³ but ≤ 20,000/mm³
• •Platelet count ≥ 50,000/mm³
• •Not pregnant
• •No uncontrolled hypertension (i.e., systolic blood pressure \> 200 mm Hg, diastolic blood pressure \> 120 mm Hg)
• •No unstable angina
• •No known bleeding disorder
• •No other contraindications for white light bronchoscopic examination
• •No other contraindications for fluorescence examination
• •PRIOR CONCURRENT THERAPY:
• •More than 3 months since prior fluorescent photosensitizing agents (hematoporphyrin derivatives)
• •More than 3 months since prior and no concurrent chemopreventative drugs (e.g., tretinoin)
• •More than 6 months since prior ionizing radiation treatment to the chest
• •More than 6 months since prior systemic cytotoxic chemotherapy
• •No concurrent anticoagulant therapy