Fatigue in Healthy Individuals

Exclusion Criteria

• •Participants with any one of the following will be excluded:
• •Inability to provide informed consent for the study;
• •Are unwilling or unable to cooperate with the study procedures or travel to NIH for the procedures;
• •Have a confirmed medical condition causing clinically significant fatigue symptom (e.g. congestive heart failure, cancer actively receiving therapy, sleep disorders);
• •Currently taking medications that cause fatigue (e.g. diuretics, beta blockers, narcotics);
• •Working late evening and night shifts within the past month;
• •Have severe psychiatric conditions (e.g. major depressive disorder, bipolar disorder, anxiety disorder, schizophrenia, drug and/or addiction abuse or dependence);
• •Report consuming more than 300mg of caffeine containing beverages (approximately 4 cups of coffee or 8 cups of soda or tea) or food (approximately 1 lb of chocolate) within 24 hours;
• •Reports consuming more than 2 servings of alcohol containing beverages every day and with detectable blood alcohol content (BAC) using breath analyzer (greater than 1 mg/dL of BAC);
• •Pregnant or lactating women.
• •Unable to refrain from smoking at least 4 hours prior to exercise testing sessions
• •Any medical condition that limits exercise performance (e.g. any condition with a ventilatory limitation during maximal exercise)
• •Any medical condition that affects participants safety with exercise (e.g.: severe heart disease, uncontrolled diabetes)