Compare the Efficacy and Tolerability of the Combination of Aripiprazole and Selective Serotonin Reuptake Inhibitors (SSRIs) Used in Major Depression

Exclusion Criteria

• •HAM-D17 item 3 score≧3.
• •Life-time history of bipolar disorders, schizophrenia or schizoaffective disorder.
• •Current history of panic disorder, obsessive-compulsive disorder, alcohol or substance abuse.
• •Mood disorder due to general medical condition.
• •Treatment with antidepressants at entry into the study before 2 weeks.
• •Need for psychoactive medications other than the study drugs, except for one benzodiazepine or hypnotic given at a stable dose.
• •Known intolerance or inefficacy to either drug.
• •Previous lack of response to two or more antidepressants at adequate dosage.
• •Subjects who have acute or unstable medical illness or organic failure.
• •Pregnancy and breast-feeding.