Treatment De-Intensification and Residual HIV-1 in Youth

Inclusion Criteria

• •081 participants must first be enrolled in either ATN 061 or ATN 071 and meet the eligibility criteria of those protocols in addition to those below.
• •061 Participants
• •Currently on treatment with an ATV/r-based HAART regimen (ATV/r, FTC, TDF is the preferred regimen);
• •HIV-1 viral load \< 100 copies at week 24;
• •CD4+ T cell count \> 350 cells/mm3 at week 24; and
• •Able to provide informed consent for the sub-study and adhere to the protocol.
• •071 Participants
• •Initiated HAART according to current DHHS guidelines (CD4+ T cells \< 350 cells/ mm3);
• •Currently on treatment with a PI-containing HAART regimen; subjects taking a protease inhibitor OTHER than ATV/r must receive approval by the team via the ATN QNS;
• •Plasma HIV-1 viral load \< 100 copies at week 24 on HAART; measurement to be collected from clinical care results contained in the medical record at the clinical site within +/- 30 days of week 24 on therapy;
• •CD4+ T cell count \> 350 cells/mm3 at week 24 on HAART; measurement to be collected from clinical care results contained in the medical record at the clinical site within +/- 30 days of week 24 on therapy; and
• •Able to provide informed consent for the sub-study and adhere to the protocol.