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Skeletal Muscle Energetics and Fatiguability in Older Individuals | Clinical Trials | Clareo Health

RECRUITING

Skeletal Muscle Energetics and Fatiguability in Older Individuals

NCT04142047•Johns Hopkins University

Summary

The investigators are studying whether metabolic abnormalities in calf (leg) muscle in older people with and others without HIV are associated with decreased abilities to exercise.

Detailed Description

This research is being done to better understand why some older people living with HIV experience more fatigue and difficulty exercising than older people without HIV. This is important because fatigue and problems exercising are predictors of disability and hospitalization in older individuals. We will use non-invasive magnetic resonance imaging (MRI) and spectroscopy (MRS) of the leg muscle to measure muscle metabolites and fat content, as well as blood samples measures levels of inflammation.

Eligibility

Age

60 - 90 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Participants who are \>= 60 years of age
•HIV serostatus positive participants on stable antiretroviral therapy (ART) (no regimen change in last month) with undetectable HIV viral load (\<100 copies).
•HIV serostatus negative participants

Exclusion Criteria

•Unable to understand the risks, benefits, and alternatives of participation and give meaningful consent
•Contraindications to MRI
•Significant cardiovascular, pulmonary or musculoskeletal or orthopedic disease that significantly limits exercise capacity
•Significant lower extremity peripheral vascular disease.
•Weight greater than 350 lbs
•Cognitive or speech impairments that would limit completion of questionnaires or fatigue reporting.

Locations (1)

Johns Hopkins Hospital

Baltimore, Maryland, United States

Key Dates

Start Date

January 3, 2019

Primary Completion Date

July 1, 2027

Completion Date

July 1, 2027

Last Updated

March 9, 2026

Enrollment

200

ESTIMATED participants

Conditions

HIVHIV Infections

Contacts

Maria Esteban, RN, BSN

CONTACT

410-955-1160 mesteba1@jh.edu

Tricia Steinberg, RN, MSN

CONTACT

443-287-3469 asteinb3@jhmi.edu

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 9, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

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Skeletal Muscle Energetics and Fatiguability in Older Individuals

Inclusion Criteria

Exclusion Criteria

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