Can Valacyclovir Delay the Need for Initiation of Human Immunodeficiency Virus (HIV) Treatment in HIV-infected Individuals?

Exclusion Criteria

• •pregnancy or actively planning to become pregnant
• •receiving chemotherapy, chronic steroid therapy or other immunomodulatory medications (e.g. interferon, azathioprine, methotrexate, TNF-alpha antagonists, etc.)
• •Estimated creatinine clearance \<30 mL/min
• •Other medical condition likely to cause death within 24 months
• •Enrolled in a therapeutic HIV vaccine or immunotherapy trial
• •Enrolled in another trial investigating the impact of another intervention on HIV disease progression
• •HIV elite controller (EC), phenotypically defined here as documented duration of HIV infection of ≥5 years, a persistent CD4 cell count ≥500 cells/mm3, and a persistent plasma HIV viral load of \<1000 copies/mL in the absence of antiretroviral therapy