The Effects of Peri-Operative Pregabalin on Post-Operative Pain Following Breast Cancer Surgery With Axillary Node Dissection: A Pilot Study

Lead Sponsor

Nova Scotia Health Authority

Age

18 - 60 years

Sex

FEMALE

Healthy Volunteers

No

•Patients 18-60 years of age, ASA I-III undergoing breast surgery with axillary dissection for the treatment of breast cancer will be considered eligible for the study.
•Informed consent for the study will be obtained prior to surgery.

•The following persons will not be considered for inclusion in the study:
•Persons undergoing breast surgery for breast cancer without axillary dissection.
•Persons undergoing cosmetic breast surgery.
•Persons undergoing concurrent breast reconstruction.
•Persons undergoing reconstruction within 12 months of surgery.
•Persons with a history of allergy to gabapentin or pregabalin.
•Persons with a history of allergy to morphine, nonsteroidal antiinflammatory drugs, acetaminophen or oxycodone.
•Persons who are or may be pregnant.
•Persons with a BMI \>40.
•Persons with severe organ dysfunction such as liver and renal failure.
•Persons receiving greater than or equal to 30 mg per day of morphine (or equivalent opioid) for pre-existing pain conditions.
•Persons previously on gabapentin or pregabalin within 3 months of surgery.
•Persons with a history of drug abuse. 13) Persons who are unable to communicate in English.

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