Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Euan J Cameron
With
University of Glasgow
NHS Greater Glasgow and Clyde
Age
18–70
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Diagnosis of asthma
Age 18-70
Current smoker
Duration of symptoms \>1yr with stability for 4 weeks
Able to maintain asthma without exacerbations during run in period
Able to wean off other asthma medication
You may not be if
Ex-smokers or never smokers
Planning to quit smoking during duration of trial
Patients with unstable asthma
Patients with current epilepsy, psychosis or history of significant atrial or ventricular tachyarrhythmia
Corrected QT-interval greater than 450msec in women, 430msec in men
Low potassium levels. If can be corrected then screening can continue with confirmation of normal levels prior to taking study medication
Liver disease (ALT and/or AST levels 2 or more times ULN)
Significant renal disease (Creatinine or urea levels 2 or more times ULN)
Any previous severe adverse reactions to macrolides
Patients who are known to have specific IgE sensitivity or skin test positivity to grass pollen and a history of worsening of asthma due to hay fever will not be recruited from mid May to the end of July
Upper or lower respiratory tract infection in the 4 weeks prior to randomisation. Run in period can be prolonged in this situation to have 4 weeks with no respiratory infection prior to randomisation.
Patients who require medications known to interact with azithromycin
On other immunosuppressants or chronic antibiotics
Weight less than 45kg
Frequent asthma exacerbations (greater than 4) requiring oral corticosteroids in the year prior to randomisation
Current or past diagnosis of allergic-bronchopulmonary-aspergillosis
Pregnancy and breast feeding
Mental impairment or language difficulties that makes informed consent not possible
