Vascular Function, Endothelin, and Inflammation in Pre-diabetic Obesity Versus Lean Healthy Controls

Exclusion Criteria

• •use of pharmacologic agents or recreational drugs, with the exception of occasional use of non-narcotic pain medications
• •blood pressure (\>140/90 mmHg)
• •elevated cholesterol (LDL \>130 mg/dL)
• •diabetes mellitus (by ADA criteria)
• •evidence of coronary and/or peripheral vascular disease by history and physical exam
• •\>5 kg change in weight in the preceding 3 months
• •chronic systemic illness with recognized metabolic effects
• •hepatitis C and HIV
• •recognized systemic inflammatory or autoimmune processes such as rheumatoid arthritis or systemic lupus erythematosis
• •Raynaud's phenomenon or other abnormalities of hand or finger perfusion
• •regular participation in endurance or high-performance athletic activity
• •history of aspirin or salsalate sensitivity including aspirin-induced asthma
• •prior treatment with salsalate, pentoxyfilline, or monoclonal anti-TNFalpha antibodies
• •pregnancy
• •liver transaminase levels \>3 times the upper limit of normal
• •creatinine \>1.5 mg/dL
• •history of a cellular immunodeficiency-related opportunistic infections, such as an endemic mycosis (eg. histoplasmosis) or mycobacterial infection (eg tuberculosis)
• •reactive tuberculin skin test
• •history of malignancy except for basal cell carcinoma of the skin