Genetics of Type 2 Diabetes in West Africans

Study Description: This protocol is designed to study the genetic basis of Type 2 Diabetes (T2D) and related conditions in Africa. Objectives: Primary Objective: To conduct genetic association studies of T2D, T2D complications, and related traits in Africans of diverse ethnic groups Secondary Objectives: * To investigate the contribution of gene x environment interactions in T2D risk and in influencing related traits * To develop a large-scale genetic epidemiological resource for the replication of findings in other studies of related traits * To conduct trans-ethnic fine-mapping * To describe the study population epidemiologically in terms of cardiometabolic traits and prevalence of related conditions * To conduct population genetic analyses to describe population history and to develop statistical techniques appropriate for genetic analyses of African ancestry individuals * To conduct deep phenotyping to facilitate additional research questions related to cardiometabolic traits and for follow-up previous findings Endpoints: Primary Endpoint: T2D Secondary Endpoints: T2D Complications, Hypertension, Obesity, Dyslipidemia, Metabolic Syndrome, Chronic Kidney Disease, and other cardiometabolic traits