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The Influence of Remote Ischemic Preconditioning on Acute Kidney Injury After Cardiac Surgery | Clinical Trials | Clareo Health

COMPLETEDPHASE1

The Influence of Remote Ischemic Preconditioning on Acute Kidney Injury After Cardiac Surgery

NCT00821522•Robert Kramer, MD

View on ClinicalTrials.gov

Summary

Acute kidney injury is associated with cardiopulmonary bypass during heart surgery and its pathogenesis is similar to that of ischemia-reperfusion injury. Remote ischemic preconditioning attenuates myocardial ischemia-reperfusion injury in patients undergoing coronary bypass surgery. The investigators hypothesize that such preconditioning reduces the incidence of acute kidney injury associated with cardiopulmonary bypass.

Eligibility

Age

18 - 80 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Patient undergoing heart surgery on cardiopulmonary bypass.

Exclusion Criteria

•Known peripheral vascular disease of the lower extremities associated with active skin necrosis or infection.
•End-stage renal disease.
•Inability to give informed consent.

Locations (1)

Maine Medical Center

Portland, Maine, United States

Key Dates

Start Date

November 1, 2008

Primary Completion Date

March 1, 2010

Completion Date

May 1, 2010

Last Updated

November 17, 2021

Enrollment

120

ACTUAL participants

Conditions

Acute Kidney InsufficiencyAcute Renal InsufficiencyAcute Kidney InjuryIschemic Preconditioning

Interventions

Remote Ischemic Preconditioning

PROCEDURE

UPTAKE: Using Personalized Risk and Digital Tools to Guide Transitions Following Acute Kidney Events

NCT05806645

Acute Kidney Injury

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RECRUITINGNA

Effects of Creatine Supplementation on Cognitive Measures and Markers of Acute Kidney Injury After Exercise in the Heat

NCT07472426

Acute Kidney InjuryExertional Heat Illness

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: November 17, 2021Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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The Influence of Remote Ischemic Preconditioning on Acute Kidney Injury After Cardiac Surgery

Inclusion Criteria

Exclusion Criteria

UPTAKE: Using Personalized Risk and Digital Tools to Guide Transitions Following Acute Kidney Events

Effects of Creatine Supplementation on Cognitive Measures and Markers of Acute Kidney Injury After Exercise in the Heat

WISDOM UK: Low Dose-intensity Versus Standard Dose-intensity CRRT in Critically Ill Patients

Outpatient Recovery From Acute Kidney Injury Requiring Dialysis - 2

Prognostic Value of Novel Biomarkers on Adverse Renal Outcomes in High-Risk Cardiac Surgery Patients

LSALT Peptide for Prevention or Attenuation of Acute Kidney Injury (AKI) in Patients Undergoing On-Pump Cardiac Surgery