A Phase 3 Study Comparing 2 Doses of CP-690,550 vs. Placebo for Treatment of Rheumatoid Arthritis

Inclusion Criteria

• •The patient has a diagnosis of RA based upon the American College of Rheumatology (ACR) 1987 Revised Criteria.
• •The patient has active disease at both Screening and Baseline, as defined by both: ≥6 joints tender or painful on motion; and ≥6 joints swollen; and fulfills 1 of the following 2 criteria at Screening: 1.ESR (Westergren method) \>28 mm in the local laboratory. 2. CRP \>7 mg/L in the central laboratory
• •Patient had an inadequate response to at least one DMARD (traditional or biologic) due to lack of efficacy or toxicity.
• •No evidence of active or latent or inadequately treated infection with Mycobacterium tuberculosis.
• •Patient has washed out of all DMARDs other that antimalarials