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RECRUITING

Chronic Pain in Rheumatoid Arthritis

CNS Pain Mechanisms in Early Rheumatoid Arthritis: Implications for the Acute to Chronic Pain Transition

NCT05038553•Northwestern University

Summary

The objective is to identify modifiable clinical factors and neurobiological pathways that lead to the development of chronic pain in patients with early rheumatoid arthritis. Participants will undergo quantitative sensory testing, a type of testing that involves assessing response to well-defined, quantifiable painful stimuli, at 0, 3, and 12 months. A subset of participants will also undergo magnetic resonance imaging at 0 and 12 months to assess neuroimaging markers that have previously been shown to be involved in chronic pain.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•1. Age ≥18 years
•2. Meet either the 1987 or 2010 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) criteria for RA
•3. Persistent joint symptoms ≤ 2 years
•4. Active inflammatory disease
•5. If taking opioids on an as needed (prn) basis, must be able to hold opioid for 12 hours before study procedures
•6. If taking NSAIDs, must be able to hold NSAIDS for 24 hours before study procedures
•7. If taking a central-acting pain medication, must be on a stable dose and able to stay on a stable dose throughout study
•1. Age ≤ 80 years old
•2. Right-handed or ambidextrous
•3. Ability to lie on their back for the duration of the MRI scans

Exclusion Criteria

•1. Routine, scheduled opioid use
•2. Routine, scheduled prednisone dose \>10 mg or its equivalent
•3. Peripheral neuropathy
•4. Peripheral vascular disease
•5. Raynaud's phenomenon requiring treatment, manifested by claudication or ischemic rest pain
•6. Uncontrolled blood pressure
•1. Severe claustrophobia precluding MRI
•2. Unable to fit comfortably in the MRI scanner (usually only occurs if body mass index \>40 kg/m2)
•3. Pregnant
•4. Contraindications to MRI

Locations (5)

University of Colorado

Denver, Colorado, United States

Northwestern University

Chicago, Illinois, United States

Johns Hopkins University

Baltimore, Maryland, United States

University of Michigan

Ann Arbor, Michigan, United States

Hospital for Special Surgery

New York, New York, United States

Key Dates

Start Date

October 12, 2021

Primary Completion Date

April 30, 2026

Completion Date

April 30, 2026

Last Updated

April 29, 2025

Enrollment

125

ESTIMATED participants

Conditions

Arthritis, RheumatoidPain

Interventions

No intervention

OTHER

Contacts

Kathleen Aren, MPH

CONTACT

312-503-1824 kathleen.aren@northwestern.edu

Mary Carns, MS

CONTACT

312-503-1137 m-carns@northwestern.edu

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: April 29, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Chronic Pain in Rheumatoid Arthritis

Inclusion Criteria

Exclusion Criteria

Effect of Virtual Reality on Patient's Comfort During Cardiac Electronic Device Implantation.

Comparison Between Tranversus Abdominis Plane (TAP) Block With Only Bupivacaine and TAP Block With Bupivacaine Plus Ketamine in Reducing Postoperative Pain After Total Abdominal Hystrectomy

A Phase Ib Study to Evaluate the Efficacy and Safety of HRS-2129 in Patients With Knee Osteoarthritis

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