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COMPLETEDPhase 4NCT00812032

Evaluation of Antiplatelet Effects of Different Dosages of Aspirin in Type 2 Diabetic Patients

The efficacy of low dose aspirin appears to be substantially lower in diabetic patients, compared to patients without diabetes. The aim of the investigators study is to test the laboratory response to...

Lead sponsor: Karolinska Institutet•1 locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

Karolinska Institutet

Age

50 - 75 years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Type 2 DM with micro- or macroangiopathy.
•HbA1c 6-9 % (Mono-S method).
•Need for, or already on-going aspirin treatment.
•Age 50-75 years
•Antecubital forearm veins allowing technically good sampling for platelet studies

Exclusion Criteria

•Diet controlled DM.
•Acute ischemic stroke, acute coronary syndrome, (myocardial infarction or unstable angina pectoris), or revascularization by PCI or by-pass surgery within the last 6 months.
•Acute or chronic kidney disease (P-cystatin C within the reference interval)
•Acute or chronic liver disease (ALAT ≤2 times the upper reference value).
•A history of gastric or duodenal ulcer disease.
•Need for treatment with anticoagulants, clopidogrel, NSAID's, or thiazolidinediones.
•Thrombocytopenia (platelet count \<150 x 109/L)
•Anticipated need for alteration of concomitant drug therapy during the course of the study.
•Enrollment in another clinical study.
•Contraindication(s) to aspirin treatment.

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: May 27, 2022Terms

Trial snapshot

StatusCOMPLETED

PhasePHASE4

Enrollment25

Start dateJan 2008

Last updatedMay 27, 2022

Condition

Type 2 Diabetes Mellitus

Locations shown

Department of Medicine, Clinical pharmacology Unit, Karolinska University Hospital, Solna.

Stockholm

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: May 27, 2022Data synced to Clareo: July 13, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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