Short-term Study of Combination Treatment of Escitalopram and Gaboxadol in Major Depressive Disorder

Exclusion Criteria

• •The patient has 1 or more of the following:
• •Any current psychiatric disorder other than MDD as defined in the DSM-IV-TR
• •Current or past history of: manic or hypomanic episode, schizophrenia, or any other psychotic disorder, including major depression with psychotic features, mental retardation, organic mental disorders, or mental disorders due to a general medical condition as defined in the DSM-IV-TR
• •Any substance disorder (except nicotine and caffeine) within the previous 6 months as defined in the DSM-IV-TR
• •Presence or history of a clinically significant neurological disorder (including epilepsy)
• •Neurodegenerative disorder (Alzheimer disease, Parkinson disease, multiple sclerosis, Huntington disease, etc)
• •Any Axis II disorder that might compromise the study
• •Previous use of hallucinogenic drug
• •The patient has a significant risk of suicide according to the investigator's opinion, or has a score \>=5 on item 10 (suicidal thoughts) of the MADRS, or has made a suicide attempt in the previous 12 months.