ERCC1 Targeted Trial

TRIAL OBJECTIVES Primary objective The trial will have two main objectives: * To detect an improvement in survival for ERCC1+ve patients treated with a non-platinum chemotherapy compared to platinum-based treatment. * To establish non-inferiority or improvement in survival for ERCC1-ve patients treated with a platinum-based chemotherapy compared to non-platinum treatment. Secondary objectives * To examine progression-free survival, response rate and quality of life between the two treatment regimens, according to ERCC1 status. * To investigate whether the treatment effect differs according to histology (squamous vs. nonsquamous);gender (males vs. females); performance status * To undertake a cost-effectiveness analysis based on all patients, and according to ERCC1 status.