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Lead
Mahidol University
To determine the additive effect of simvastatin on airway inflammation in ICS-treated patients with persistent asthma by measuring eosinophil counts in induced sputum
Age
18–70
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
He or she has FEV1 \> 60% of predicted
He or she requires less than 1000 mcg daily of beclomethasone or equivalent
You may not be if
He or she had previous history of renal disease or serum creatinine more than 2 mg/dL
He or she had previous history of liver disease
She is pregnant or during lactation
He or she has already received statins or is allergic to statins or has developed myositis.
He or she has an asthma exacerbation and requires treatment with oral corticosteroids during the 3 months prior to the commencement of study entry.
Clareo Health | The Additive Anti-inflammatory Effect of Simvastatin in Combination With Inhaled Corticosteroids in Asthma
