Body Weight Effects on Glucophage's Efficacy in Chinese Diagnosed T2DM Patients

Exclusion Criteria

• •Women of child bearing potential
• •body mass index (BMI)≥35 Kg/m2 or BMI \<18.5 Kg/m2
• •Hemoglobin A1c (HbA1c)\>10.0% or \<7.0%
• •Active liver disease and/or significant abnormal liver function
• •Acute or chronic metabolic acidosis, including diabetic ketoacidosis, with or without coma
• •Congestive heart failure defined as New York Heart Association (NYHA) class III or IV and /or left ventricular ejection fraction ≤40%
• •Significant cardiovascular history with the past 6 months
• •Severe retinopathy, persistent uncontrolled hypertension (SBP≥180mmHg, or DBP≥105mmHg)
• •Severe chronic gastrointestinal disease
• •History of alcohol abuse or illegal drug abuse within the past 12 months
• •Diagnosed anemia
• •Creatine kinase ≥3 X ULN
• •Serum creatinine ≥1.5 mg/dL(133μmol/L) \[males\], ≥1.4 mg/dL(124 μmol/L)\[females\]
• •Alanine amino transferase (ALT) and/or aspartate amino transferase (AST)\> 1.5 X ULN and/or total bilirubin \> 2 X ULN
• •Hemoglobin \<12g/dL \[males\], \<11g/dL \[females\]
• •Allergies and Adverse Drug Reactions
• •Prohibited Treatments and/or Therapies
• •Prisoners or subjects who are involuntarily incarcerated
• •Subjects who are compulsorily detained for treatment of either a psychiatric or physical (eg, infectious disease) illness
• •Subjects decline to participate