Drug Interaction Study of Rifampin and Warfarin in Healthy Volunteers.

Exclusion Criteria

• •Subjects on prescription or chronic over-the counter medications (including hormonal contraceptives);
• •Subjects with known allergy to warfarin and/or rifampin;
• •Subjects who are not homozygous for cytochrome P450 2C9 (CYP2C9 \*1) (known poor metabolizers).
• •Subjects with a history or diagnosis of hemorrhagic tendencies or blood dyscrasias;
• •Subjects with liver failure or liver function test (LFT) results \>2x upper limit of normal;
• •Subjects with clinically significant elevations in international normalized ratio (INR), prothrombin (PT), prothrombin time (PTT), serum creatinine (SCr), blood urea nitrogen (BUN) or other screening laboratory tests as determined by study physician;
• •Subjects with Hct \<30 mg/dL;
• •Subjects with history of GI bleed or peptic ulcer disease;
• •Subjects with a recent history of trauma;
• •Subjects with a recent history of or upcoming plan of surgery;
• •Subjects who smoke tobacco;
• •Subjects with ongoing alcohol or illegal drug use;
• •Subjects who are pregnant, lactating or attempting to conceive;
• •Subjects unable to maintain adequate birth control during the study;
• •Subjects unable to follow protocol instructions or protocol criteria.