Muscle Lipid and Insulin Resistance in the Elderly

Exclusion Criteria

• •Clinically significant CVD including h/o MI
• •Peripheral Vascular Disease
• •Hepatic, renal, muscular/neuromuscular, or active hematologic/oncologic disease
• •Clinically diminished pulse
• •Presence of bruits in lower extremities
• •Previous history of pulmonary emboli
• •Peripheral Neuropathy
• •Currently not engaged in a regular program and have a V)2 max pre-training value \> 55 ml/kg-fat free mass-min., indicative of moderate fitness OR currently engaged in regular program and having a V)2 max value \< 55 ml/kg-fat free mass-min.
• •Anemia (Hematocrit \< 34%)
• •Any contraindications to moderate exercise
• •Inability and/or willingness to comply with the protocol as written
• •Active alcohol or substance abuse (Past 5 years)
• •Total cholesterol \> 300 mg/dL
• •Triglyceride \> 350 mg/dL
• •ALT \> 80, AST \> 80, Alk Phos \> 240
• •Proteinuria (defined as \> 1+ on routine dipstick) hypothyroidism (sTSH\>8)
• •Therapeutic Doses of Nicotinic Acid
• •Type 2 Diabetes: Fasting Glucose \> 126 mg/dl or 2 hour glucose \> 200 mg/dl
• •Oral Glucocorticoids
• •Females currently on hormone replacement therapy (HRT) less than 6 months
• •Claustrophobia
• •Previous difficulty with lidocaine or other local anesthetic
• •Stress test symptoms:
• •* Positive ECG (\>2mm ST segment depression) without PCP cardiologist permission to participate
• •* Signs or symptoms of cardiovascular decomposition (hypotensive response to exercise
• •* Onset of angina or angina like symptoms, shortness of breath, change in heart rhythm, signs of poor perfusion (light-headedness), tightness
• •* Hypotension