Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Forest Laboratories
Age
18–85
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Male or female, 18-85 years of age
Blood pressure in the range of 130 to 179/80 to 109 mmHg
Currently using either an ACE inhibitor or an ARB alone or (an ACE inhibitor or an ARB and up to two other drugs for treatment of high blood pressure). (Patients may be on both an ACE inhibitor and ARB, but would need to be taken off one.)
Stable medication regimen for high blood pressure for at least one month prior to screening
Stable type 2 diabetes mellitus for at least 3 months prior to screening that is controlled by any or all of the following: diet and antidiabetic medications that may include fixed-dose insulin
HgbA1c 6.5 to 8.5% (This is measured at the screening visit)
You may not be if
Use of any beta blocker within one month prior to screening
Use of clonidine within 3 months prior to screening
Diagnosis of hyperthyroidism as evidenced by abnormal lab markers
Any disorder requiring the intermittent or chronic use of systemic corticosteroids
Diagnosis of hyperthyroidism as determined by lab markers done at screening
Active liver disease as determined by lab markers
Kidney impairment; estimated GFR \< 60 mL/min/1.73 m2
History of heart attack, clinically significant arrhythmia, unstable angina, coronary angioplasty/bypass surgery, stroke, or TIA in 3 months prior to screening
Chronic heart failure
Drug or alcohol abuse within 2 years prior to screening
History of sensitivity to any beta blocker, HCTZ, sulfa drug, or calcium channel blocker
Participation in another research study within 30 days prior to screening
