Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Stage I-IIIB Non-Small Cell Lung Cancer After Completion of Radiation Therapy Alone or Combined Radiation Therapy and Chemotherapy

Patients must be \>= 18 years of age.

Patients must have a Karnofsky performance status of \>= 60%.

Patients must have histological confirmation non-small cell lung cancer and must have tumors that produce CEA as documented by either immunohistochemistry or by an elevated serum CEA level.

Patients must have American Joint Committee on Cancer (AJCC) Version 7 Stage I-IIIB non small cell lung cancer (NSCLC) who are not a surgical candidate due to unresectability or medical inoperability.

Patients must have undergone radiation therapy alone, or radiation therapy plus systemic therapy (which includes chemotherapy or tyrosine kinase inhibitors) as treatment for their lung cancer; patients may receive up to two cycles of consolidative chemotherapy after radiation therapy +/- chemotherapy; this therapy must be completed within 6-12 weeks prior to starting treatment on this trial.

Patients must have had measurable or evaluable disease prior to receiving standard radiation therapy alone, or radiation therapy plus systemic therapy.

Patients must have no evidence of progressive disease (therefore, must have stable disease, partial response or complete response) to the therapy given prior to enrollment on this study.

No radiotherapy, immunotherapy, or chemotherapy within the last 5 years prior to the diagnosis of locally advanced NSCLC; prior adjuvant chemotherapy or tyrosine kinase inhibitor therapy for early stage, resected NSCLC is allowed as long as it was given \> 12 months prior to the current diagnosis of locally advanced NSCLC.

Patients must demonstrate an forced expiratory volume in one second (FEV1) \>= 0.9.

Adequate bone marrow function as evidenced by hemoglobin \>= 10 gm %, WBC \>= 3500/ul, an absolute granulocyte count of \>= 1,500/mm3, and platelets \>= 140,000/ul. Patients may be transfused to reach a hemoglobin \>=10 gm %.

Patients must have a total bilirubin \<= 1.5 mg/dL and liver transaminases no higher then 2 times the upper limit of normal.

Patients must have serum creatinine \<= 1.5 x upper limit of normal (ULN) and a creatinine clearance \>= 45 cc/min (based on Cockcroft Gault formula).

Patients must not have post-obstructive pneumonia or other serious infection.

If a patient has previously received murine or chimeric antibody, then serum anti-antibody testing must be negative.

Serum HIV testing and hepatitis B surface antigen and hepatitis C antibody testing must be negative.

Women of childbearing potential must have a negative serum pregnancy test prior to entry and while on study must be practicing an effective form of contraception.

What this study is about