Lead Sponsor

Merck Sharp & Dohme LLC

Collaborators

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•You must have confirmed metastatic or advanced cancer that has not responded to standard therapy or where standard therapy does not exist
•In Part C, patients must have a diagnosis of advanced or metastatic colorectal adenocarcinoma or non-small cell lung cancer, and must have received at least 1 but no more than three prior systemic therapy treatment regimens
•You must be over the age of 18 years old
•You must have a ECOG status performance of 0 or 1
•You must have good organ function
•You must be willing to have skin and/or tumor biopsies

•You have had cancer treatment within 4 weeks prior to entering the study or you still have bad side effects from previous therapies
•You have an active infection that requires treatment
•You are HIV positive or have a history of Hepatitis B or C