Trial of Linaclotide in Patients With Chronic Constipation

Inclusion Criteria

• •Patient has completed a colonoscopy according to the AGA criteria, with no clinically significant findings
• •Patient has successfully completed protocol procedures (with no clinically significant findings): physical exam, 12-lead ECG, or clinical laboratory tests
• •Patient meets protocol criteria for CC: reports \< 3 bowel movements per week and reports straining, lumpy or hard stools, and/or sensation of incomplete evacuation during \> 25% of BMs
• •Patient demonstrates continued chronic constipation through Pretreatment Period
• •Patient is compliant with IVRS