Known or suspected causes of secondary hypertension
Patient with bilateral renal artery stenosis, renal artery stenosis in a solitary kidney; history of renal transplant or only has one functioning kidney
Associated cardiovascular conditions that prevent the patient from stopping the current antihypertensive drug (e.g.: Beta-blocker for angina, ACE-inhibitors for heart failure, etc…).
Known hypersensitivity to diuretics or sulphonamides or history of angioedema or cough related to the administration of an angiotensin II receptor antagonist or any combination of the drugs used
Known contraindications to the study drugs:
Severe renal dysfunction (creatinine clearance \<30ml/min)
Known hypokaliemia (\< 3 mmol/L) , known hypercalcemia
Severe hepatic impairment, biliary cirrhosis, cholestasis
Inability to obtain a valid automatic BP measurement recording
Administration of any other investigational drug within 30 days prior to study entry and during the course of the study
Presence of any severe medical or psychological condition that, in the opinion of the investigator, indicate that participation in the study is not in the best interest of the subject.
Presence of any other conditions (e.g. geographic, social, etc) that would restrict or limit the subject participation for the duration of the study.
Pregnant or breast-feeding women
Women of childbearing potential not protected by effective contraceptive method of birth control
The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.
Clareo Health | ACTUAL: Efficacy and Safety of Irbesartan/Hydrochlorothiazide Combination
