Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of California, Davis
With
National Alliance for Research on Schizophrenia and Depression
Candidate with bipolar depression will be screened after signing informed consent. Those who meet the selection criteria will be treated with daily rTMS for 3 weeks and be followed-up at 2 weeks. Participants will keep their ongoing medication unless a medication significantly increases the possibility of seizure. They must be on the same dose of antidepressant medication for least 4 weeks without improvement of symptoms before being recruited into the study. Mood and other observed mental status will be measured by standard psychological scales.
Age
18–65
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
bipolar I or II patients, currently in a depression episode
Patient must have failed at least 2 medication
Score of 21-item Hamilton Rating Scale for Depression (HAM-D)
You may not be if
Rapid cycling bipolar or mixed episode of mood disorder by definition of current DSM criteria
Substantial risk of suicide during the screening period that requires inpatient care
Presence of psychosis
Dual diagnosis of other primary, currently clinically significant severe mental disorders
History of other significant neurological diseases, such as seizure disorder, stroke, brain tumors, abnormalities in the blood vessels in brain, dementia, Parkinson's disease, Huntington's chorea or multiple sclerosis
History of any medical event that may increase the risk of having seizure, such as head trauma with unconsciousness for more than 5 minutes or a family history of seizure
Significant medical complications that may deteriorate during the trial or have increased likelihood of danger consequences
Patients who are pregnant or intend to become pregnant during the study period
Any metallic prosthesis in head, neck or upper body (including cardiac pace maker) that cannot be safely removed during treatment
Current Vagus Nerve Stimulation (VNS) treatment or Electroconvulsive Therapy (ECT) treatment, or with history of failed ECT treatment
Patient's Motor Threshold for TMS cannot be detected
Significant side effects which are intolerable during the screening or any later stage of the trial
Started psychotherapy within the previous 8 weeks or foreseeable psychotherapy will be started or changed in 6 weeks
