Effect of Carvedilol Controlled-Release (CR) and Atenolol on Central Blood Pressure

Exclusion Criteria

• •Secondary forms of hypertension (including sleep apnea)
• •Patients currently treated with two or more antihypertensive drugs
• •Patients taking antihypertensive drugs with properly measured clinic systolic blood pressure greater then 170mmHg
• •Isolated systolic hypertension
• •Other diseases requiring treatment with blood pressure lowering medications
• •Heart rate less then 55 beats/min (in the absence of beta-blocker therapy)
• •Known cardiovascular disease including history of angina pectoris, heart failure, presence of a cardiac pacemaker, history of myocardial infarction or revascularization procedure, or cerebrovascular disease (including stroke and TIA)
• •Known diabetes mellitus (Type 1 or 2)
• •Renal insufficiency defined as a serum creatinine greater then 1.5mg/dL in males and 1.4mg/dL in females
• •Primary renal disease
• •Pregnancy or lactation
• •History of Raynaud's syndrome
• •Alcoholism and recreational drug use (due to compliance concerns)