Assessment of Whole Gut Transit Time Using the SmartPill Capsule

Exclusion Criteria

• •Previous history of bezoars.
• •Prior GI surgery except for cholecystectomy, appendectomy, or Nissen fundoplication
• •Any abdominal surgery within the past 3 months
• •Known or history of inflammatory bowel disease
• •History of diverticulitis, diverticular stricture, and other intestinal strictures
• •Tobacco use within eight hours prior to capsule ingestion and during the initial 8 hour recording on Day 0 or the Ingestion visit.
• •Alcohol use within eight hours prior to capsule ingestion and throughout the entire monitoring period (5 days).
• •BMI \> 38
• •Allergies to components of the SmartBar (Appendix IX).
• •Females of childbearing age who are not practicing birth control and/or are pregnant or lactating. (A urine pregnancy test will be performed on female subjects prior to capsule ingestion).
• •Cardiovascular, endocrine, renal, or other chronic disease likely to affect motility.
• •Use of medical devices such as pacemakers, infusion pumps, or insulin pumps.
• •Any contraindication to use of Fleets Enema or balloon expulsion test.
• •Uncontrolled diabetes with a hemoglobin A1C greater than 10.