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MR Spectroscopy as a Diagnostic and Outcome Measure in Pain and SCI | Clinical Trials | Clareo Health

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MR Spectroscopy as a Diagnostic and Outcome Measure in Pain and SCI

MR Spectroscopy (MRS) as a Diagnostic and Outcome Measure in Pain and SCI

NCT00561782•US Department of Veterans Affairs

Summary

The goal of this study is to compare the changes that occur in sensation and chemical properties of the brain following SCI between individuals that experience chronic pain and those that do not, and between those with SCI and the able-bodied.

Detailed Description

This study investigates the differences in certain neurochemicals present in areas of the brain linked to pain processing in people with SCI and neuropathic pain, in people with SCI but no pain, and in able-bodied persons. We will also investigate the relationship between these concentrations of neurochemicals and different aspects of chronic neuropathic pain, including the intensity of pain, quality of life issues, sensitivity changes in areas of the body that are both painful and non-painful, and neurological status.

Eligibility

Age

18 - 70 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•1. SCI and neuropathic pain:
•* fluent in English
•* incomplete or complete traumatic SCI
•* the injury must have occurred at least 2 years prior to entering the study
•* the injury level must be above L1 and the subjects must have evidence of preserved distal cord functions (lower extremity reflexes and bulbocavernosus or anal wink reflexes)
•* must have experienced chronic neuropathic pain at or below the level of injury for a minimum of six months
•* must have moderately severe or greater neuropathic pain
•* must be able to attend three sessions ranging from 2 to 6 hours over a period of 4 to 5 weeks
•2. SCI and no neuropathic pain:
•\- same as a., but participants in this group must NOT have unremitting moderate-severe pain and there will only be two sessions ranging from 2 to 6 hours over a period of 1 to 2 weeks
+5 more criteria

Exclusion Criteria

•current pregnancy or women who are contemplating pregnancy
•recent (one-year) history of alcohol or drug abuse
•known intra-cerebral pathology or epilepsy
•MRI findings indicative of intra-cerebral pathology
•significant post-traumatic encephalopathy from head trauma sustained at SCI or cognitive impairment indicative of traumatic brain injury
•current diagnosis of DSM-IV Axis I disorder
•inability to meet the MRI screening requirements (including, but not limited to, the presence of a pacemaker or other electronic devices, prosthesis, artificial limb or joint, shunt, some metal rods, some tattoos, or moderate to severe claustrophobia or anxiety)

Locations (1)

VA Medical Center, Miami

Miami, Florida, United States

Key Dates

Start Date

October 1, 2007

Primary Completion Date

November 1, 2010

Completion Date

November 1, 2010

Last Updated

September 17, 2014

Enrollment

ACTUAL participants

Conditions

Spinal Cord InjuryHyperalgesia, SecondaryHyperalgesic Sensations

Spinal Cord Stimulation (SCS) for Spinal Cord Injury (SCI)

NCT04894734

Spinal Cord Injury at T1-T12 LevelTraumatic Thoracic Spinal Cord Contusion+4 more

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RECRUITINGNA

VR Mindfulness Training for Veterans With SCI

NCT06587607

Spinal Cord InjuryChronic Pain

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: September 17, 2014Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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MR Spectroscopy as a Diagnostic and Outcome Measure in Pain and SCI

Inclusion Criteria

Exclusion Criteria

Spinal Cord Stimulation (SCS) for Spinal Cord Injury (SCI)

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