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Lead
Rambam Health Care Campus
We aimed to gather information concerning methacholine challenge test performed in children previously diagnosed with asthma (asthmatics) and 48 had prolonged cough (coughers) from the pediatric clinic at Meyer Children's Hospital.
Tests were performed by inhalation of triple-concentration increments (0.06 to13.9mg/ml/methacholine).
Spirometry was determined at baseline and after each inhalation in duplicate sets. End of test was defined by a fall of 20%FEV1 baseline (PC20-FEV1). PC20-FEV1\<4.0mg/ml was considered positive). Results from the challenge were related to data from questionnaires concerning respiratory symptoms were analyzed at the end of the studies.
Age
3–6
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
age 3- to 6-years
respiratory diseases who were highly indicative of asthma diagnosis according to GINA guidelines \[9\]
cough duration of more than 4 weeks
normal chest auscultation and baseline FEV1\>75% predicted for healthy preschool children, on the day of testing.
You may not be if
presence of other chronic respiratory conditions
emergency room visit or the presence of respiratory infection within the last month
oral or inhaled steroids or other anti-inflammatory medication taken in the last two weeks
bronchodilator taken within 24-hours prior to the test.
Clareo Health | Spirometry and Methacholine Challenge Test in Asthmatic Children Age 3-6years
