Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Laval University
Primary Outcome Measures :
Airway inflammation and remodeling: in bronchial biopsies
Secondary Outcome Measures:
Comparisons of bronchial biopsy features between groups:
* Bronchial epithelial morphology
* Bronchial mucosa (smooth muscle, reticular basement membrane, submucosal gland,...)
Age
18–65
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
In remission of their asthma: absence of respiratory symptoms, no rescue asthma medication need and (for complete remission) an optimal pulmonary function (FEV1 \> 90%) and normal PC20 methacholine for more than two years (with no current treatment).
With a proven past history of asthma from medical files (reversible airway obstruction (\> 12% FEV1 after bronchodilator or 20% by other means) proven by spirometry, PEF measures or methacholine challenge according to current criteria + previous symptoms and asthma medication use), having no more asthma symptoms and not having used asthma medication for more than 2 years.
Agree to sign the consent form.
No other condition that could interfere with the study measurements.
You may not be if
Subjects using inhaled or oral anti-inflammatory agents.
FEV1 \< 1.2 L.
Unable to adhere to the protocol requirements.
Other current respiratory disease
Upper or lower respiratory tract infection or use of antibiotics \< 1 month.
Use of oral corticosteroids within the last 3 months.
Signs or symptoms of progressive or uncontrolled renal, hepatic, hematologic, endocrine, pulmonary, cardiac, neurologic or cerebral disease.
Clareo Health | Bronchoscopy With Bronchial Biopsies Sub-study of: Persistence of Airway Inflammation and Remodeling in Asthma Remission
