MQX-503 vs Nitroglycerin Ointment: A Pharmacokinetic Comparison in Normal Subjects

Exclusion Criteria

• •Persons who would be put at risk by discontinuing prescription therapies.
• •Subjects with a known allergy to nitroglycerin.
• •Subjects who have a condition or issue that would adversely affect the application of study medication, study evaluations or the subject's ability to comply with the protocol.
• •Subjects who recently experienced myocardial infarction, uncontrolled congestive heart failure, unstable angina, uncontrolled hypotension or uncontrolled hypertension.
• •Subjects who have participated in a study of an investigational drug within two weeks of visit 1.
• •Subjects who have screening lab values that are out of range or are considered clinically significant by the investigator.
• •Subjects who have had major abdominal, thoracic, or vascular surgery within 6 months of visit 1.
• •Subjects with non-epithelialized skin lesions or interfering skin conditions at the time of screening in the area where study medication is to be applied.
• •Pregnant or nursing women.
• •Women of childbearing potential who are unwilling to comply with the contraceptive requirements.