Phase II, Randomized, Placebo-Controlled Study of ATI-7505 in Patients With Chronic Idiopathic Constipation

Exclusion Criteria

• •transabdominal surgery, unstable coronary artery disease, organic gastrointestinal disease, collagen vascular disease, or any alarm symptoms within the 6 months prior to screening;
• •taking prohibited medications (including laxatives, herbal remedies)
• •participating in another drug or medical device study or use of any investigational drug within 30 days before dosing or planning to use prior to study completion;
• •QTcB \>440 msec, abnormal 12-lead ECG, family history of sudden death at age \<40 years or history of long QT syndrome
• •alcohol or drug abuse within the 6 months prior to screening;
• •autonomic dyssynergic defecation