The Safety and Efficacy of Fecal Microbiota Transplantation Combined With Nutritional Intervention in the Treatment of Functional Constipation：a Pilot Study

Inclusion Criteria

• •1. Age: 18 to 70.
• •2. Diagnostic criteria: Functional constipation (FC) in accordance with Rome IV criteria, which should meet the following conditions:
• •* Symptom requirements: The following at least 2 items should occur in ≥25% of bowel movements: a. Straining during defecation; b. Hard stool (Bristol Stool Classification score 1-2); c. Feeling of incomplete evacuation; d. Rectal obstruction sensation; e. Need for finger assistance during defecation; f. Spontaneous bowel movements \<3 times per week.
• •* It is rare to have loose stools without laxatives.
• •* Exclusion of irritable bowel syndrome (IBS): IBS diagnosis criteria not meeting Rome IV.
• •* Disease course requirements: Symptoms persist for at least 6 months and meet the above criteria within the last 3 months.
• •3. Traditional treatment methods (dietary intervention, at least two laxatives or probiotics) are ineffective.