Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Sanofi
Age
18–80
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Established essential hypertension, untreated or treated but uncontrolled with treatment:
* Office SBP ≥ 160 mmHg for untreated patients
* Office SBP ≥ 140 mmHg for patients already treated with an antihypertensive drug.
Previous antihypertensive therapy must have been implemented for a minimum of 4 weeks and must be either monotherapy or one of the following permitted combination drugs:
* ACE inhibitor / calcium channel blocker
* Beta blocker / calcium channel blocker
* Beta blocker / low dose diuretic
* ACE inhibitor / low dose diuretic
You may not be if
SBP ≥ 180 mmHg and/or DBP ≥ 110 mmHg evaluated at doctor's office at Visit 1
Known or suspected causes of secondary hypertension
Patient with bilateral renal artery stenosis, renal artery stenosis in a solitary kidney, a renal transplant or only has one functioning kidney
Type 1 diabetes mellitus
Significant cardiovascular, neurological, endocrine, renal, metabolic, or gastrointestinal disease, a malignancy or any other diseases considered by the Investigator to make participation in the study not in the best interest of the subject
Known hypersensitivity to diuretics or sulphonamides or history of angioedema or cough related to the administration of an angiotensin II receptor antagonist or any combination of the drugs used
Known contraindications to any of the study drugs
Concomitant use of any other antihypertensive treatment
Use of any of the investigational products for this study within the 3 months prior to the study
Inability to obtain a valid HBPM recording i.e., obesity, arm circumference \> 32 cm or arrhythmia
Administration of any other investigational drug in the last 30 days before enrolment and during the course of the study
Pregnant or breast-feeding women
Women of childbearing potential not protected by effective contraceptive method of birth control and/or who are unwilling or unable to be tested for pregnancy
The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.
Clareo Health | Efficacy of Irbesartan/Hydrochlorothiazide Versus Valsartan/Hydrochlorothiazide in Mild to Moderate Hypertension
