Clinically significant renal or hepatic disease

Presence of anemia

Presence of unstable or severe angina, coronary insufficiency, or any congestive heart failure requiring therapy

Systolic blood pressure \>170mmHg or diastolic blood pressure \>100mmHg, while on anti-hypertensive treatment

Chronic disease requiring intermittent or chronic treatment with corticosteroids

Any female lactating, pregnant, or planning to become pregnant

History of hepatocellular reaction, severe edema or a medically serious fluid related event associated with any thiazolidinedione

Presence of acute or chronic metabolic acidosis

History of diabetic ketoacidosis

Efficacy and Safety Study of Rosiglitazone/Metformin Therapy vs Rosiglitazone and Metformin in Type 2 Diabetes Subjects