A Study of LY4057996 in Healthy Participants and Participants With Type 1 and Type 2 Diabetes

Inclusion Criteria

• •Part A for Healthy Participants:
• •Are overtly healthy as determined by medical evaluation, including medical history, physical exam, laboratory tests, and cardiac screening assessment
• •Part A for Type 2 Diabetes (T2DM) Participants:
• •Are participants with T2DM diagnosed greater than 1 year before enrollment,
• •On basal insulin therapy, insulin glargine, insulin detemir, or insulin degludec, greater than 10 units per day for at least 6 months (for Cohort 5 only)
• •Glycated hemoglobin (HbA1c) 6.5% to 9.5% inclusive at screening
• •Part B
• •Have Type 1 Diabetes (T1D) for at least 1 year with a fasting C-peptide level of 0.20 nanomole per liter (nmol/L) or less or non-fasting C-peptide level of 0.30 nmol/L or less at screening
• •HbA1c 6% to 8.5% inclusive at screening
• •Part C
• •Have T1D for at least 1 year with a fasting C-peptide level of 0.20 nanomole per liter (nmol/L) or less or non-fasting C-peptide level of 0.30 nmol/L or less at screening
• •HbA1c 6 to 8.5% inclusive at screening
• •All Parts
• •Have blood pressure of less than 140/90 millimeters of mercury (mmHg) for healthy participants or 150/90 mmHg for participants with diabetes and pulse rate of less than 90 beats per minute (bpm) (supine)
• •No hypoglycemia unawareness for all Type 1 and Type 2 Diabetes participants