A Randomized, Placebo-Controlled Trial to Examine the Efficacy of Oral Donepezil in Subjects With MCI

Inclusion Criteria

• •Healthy males or females ages 55-90 inclusive (Healthy is defined as no clinically relevant abnormalities identified by a detailed medical history, full physical examination, including blood pressure and heart rate measurement, 12-lead ECG and clinical laboratory tests)
• •Body Mass Index (BMI) between 18 to 34 kg/m2, inclusive; and a total body weight
• •Subjects with mild cognitive impairment (MCI) must have a reliable informant who has an average of 10 hours per week or more contact with the subject.
• •Memory complaints and memory difficulties, which are verified by an informant
• •Mini-mental status exam (MMSE) score of 24-30