Lead Sponsor

SK Chemicals Co., Ltd.

Age

55 - 85 years

Sex

ALL

Healthy Volunteers

No

•Age range : 50 \~ 85 years
•Clinical diagnosis of probable Alzheimer's disease (DSM-IV and NINCDS-ADRDA criteria)
•MRI within the last 12 months consistent with a diagnosis of AD
•MMSE score 10 to 26
•AChEI or memantine was discontinued at least 3 months prior to screening

•Patient in mild cognitive impairment (MCI; CDR-SB \<2.5)
•Other central nervous disease
•hypothyroidism, Vitamin B12/ Folic acid deficiency, hypercalcemia, neurosyphilis, AIDS
•T.I.A or Major infarction within the last 12 months
•Any serious disorder that could limit the ability of the patient to participate in the study
•COPD or asthma
•Any condition which would make the patient or the caregiver, in the opinion of the investigator, unsuitable for the study