An Open-Label, Randomized, Comparative 3-Way Cross-Over Study to Evaluate the Effect of Food on the 24-Hour Intragastric pH at Day 5 After Twice Daily Oral Administration of PN 200 (Omeprazole/Naproxen) in Healthy Volunteers

Inclusion Criteria

• •1. Male or non-lactating, non-pregnant female subjects who are 18-55 years of age
• •2. Female subjects are eligible for participation in the study if they are of:
• •* Non-childbearing potential (i.e., physiologically incapable of becoming pregnant); or,
• •* Childbearing potential, have a negative pregnancy test (urine) at screening, and at least one of the following applies or is agreed to by the subject:
• •* Female sterilization or sterilization of male partner; or,
• •* Hormonal contraception by oral route, implant, injectable, vaginal ring; or,
• •* Any intrauterine device (IUD) with published data showing that the lowest expected failure rate is less than 1% per year;
• •* Double barrier method (2 physical barriers or 1 physical barrier plus spermicide); or
• •* Any other method with published data showing that the lowest expected failure rate is less than 1% per year
• •3. Physical examination findings within normal limits for age
• •4. Able to understand and comply with study procedures required and able and willing to provide written informed consent prior to any study procedures being performed