Imatinib Mesylate and Bevacizumab After First-Line Chemotherapy and Bevacizumab in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer

You may be eligible if

• DISEASE CHARACTERISTICS:
• Histologically or cytologically confirmed non-small cell lung cancer
• * Stage IIIB (by pleural effusion only) or stage IV disease
• * No predominately squamous cell carcinoma
• * Mixed tumors will be categorized by predominant cell type
• Must have completed 4 courses of platinum-based, doublet chemotherapy and bevacizumab\*, has no disease progression, and meets the following criteria:
• * Platinum agent may have included carboplatin or cisplatin
• * Second agent may have included paclitaxel, docetaxel, gemcitabine hydrochloride, vinorelbine ditartrate, or pemetrexed disodium
• * A change in the platinum doublet is acceptable provided the following are true:
• * Basis for change was toxicity rather than disease progression
• * Total number of courses of any platinum doublet plus bevacizumab was 4
• * At least 3 of 4 courses must have included bevacizumab NOTE: \*Patients age 70 and over may have completed 4 courses of single-agent chemotherapy plus bevacizumab; single agent chemotherapy may have included paclitaxel, docetaxel, gemcitabine hydrochloride, vinorelbine ditartrate, or pemetrexed disodium
• No brain metastases by brain MRI or head CT scan
• PATIENT CHARACTERISTICS:
• ECOG performance status 0-1
• Bilirubin ≤ 1.25 times upper limit of normal (ULN)
• AST and ALT ≤ 2.5 times ULN
• Creatinine ≤ 1.5 times ULN
• Absolute neutrophil count ≥ 1500/mm³
• Platelet count ≥ 100,000/mm³
• INR ≤ 1.5 times ULN
• Urine protein:creatinine ratio ≤ 1
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective barrier contraception during and for 3 months after completion of study treatment
• No history of gross hemoptysis (defined as \> ½ teaspoon of bright red blood)
• No inadequately controlled hypertension (defined as blood pressure \> 150/100 mm Hg on antihypertensive medications)
• No significant traumatic injury within the past 28 days
• No condition requiring continuous administration of systemic corticosteroids
• No medical condition that would preclude study treatment
• No medical comorbidities, including any of the following:
• * Unstable angina
• * Congestive heart failure ≥ grade 2
• * Myocardial infarction within the past 6 months
• * Stroke within the past 6 months
• * Peripheral vascular disease ≥ grade 2 within the past 6 months
• PRIOR CONCURRENT THERAPY:
• See Disease Characteristics
• No prior systemic chemotherapy in the metastatic setting, except for 4 courses of platinum-based, doublet chemotherapy plus bevacizumab in the first-line setting
• * Prior adjuvant, neoadjuvant, or combined modality chemoradiation for localized non-small cell lung cancer allowed provided ≥ 6 months elapsed before metastatic recurrence
• At least 28 days since prior major surgical procedure
• No prior antiangiogenic drug, including AMG 706, CP-547, 632, vatalanib, AZD2171, thalidomide, sorafenib tosylate, or sunitinib malate
• No other concurrent investigational drugs
• No concurrent grapefruit juice or products containing grapefruit
• No other concurrent anticancer agents, including chemotherapy and biological agents
• No concurrent major surgical procedure
• No concurrent therapeutic coagulation comprising warfarin, heparin, or low molecular weight heparin
• * Low-dose warfarin (e.g., 1 mg/day) for prophylaxis of central venous catheter thrombosis allowed
• No chronic daily acetylsalicylic acid (\> 325 mg/day) or other full-dose nonsteroidal anti-inflammatory drug with antiplatelet activity