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Keep this study
Lead
University of Glasgow
With
Chief Scientist Office of the Scottish Government
Smokers with asthma display a relative insensitivity to inhaled and oral corticosteroids. The causes of this phenomenon are currently unknown. However research into steroid resistance in severe asthma and the smoking related condition chronic obstructive pulmonary disease (COPD) points to a number of possible causes. We will characterise a group of smokers with asthma and perform a number of investigations and compare the results to ex-smokers and never smokers with asthma with the aim of establishing which previously published steroid resistance phenomena are related to the steroid resistance displayed by smokers with asthma. Results produced from this trial will provide hypothesis generating information leading to future pharmaceutical trials.
Age
18–60
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Asthma (defined by either reversibility to bronchodilator or methacholine testing)
Asthma duration of 6 months or greater
Stable asthma
Age 18-60
Treatment with inhaled corticosteroids
Smoking history consistent with group
* smokers with asthma: \> or = 5 pack years and currently smoking more than 5 cigarettes per day
* ex-smokers: smoking ceased \> or = two years prior to recruitment, minimum 5 pack year history
* non-smokers: no smoking history
You may not be if
Presence of medical condition likely to be exacerbated by treatment with oral corticosteroids
Treatment with \> 2000 mcg beclomethasone (or equivalent) per day
Subject requires oral corticosteroids to maintain asthma control
Subject requires oral theophylline to maintain asthma control
Recent treatment with oral corticosteroids
Pregnancy or subject planning to become pregnant
Clareo Health | Determinants of Corticosteroid Insensitivity in Smokers With Asthma
