A Study in Healthy Subjects to Assess How Dosing of Rifampin Affects What the Body Does to a Dose of GW679769 (Casopitant).

Exclusion Criteria

• •smokes at least 4 packs per day in the past 12 months
• •use of prescription or non-prescription drug(s)
• •herbal or dietary supplements or vitamins with 14 days prior to first dose of study medication
• •a clinically relevant abnormality medical condition or circumstance making the subject unsuitable for the study per the study doctor
• •blood donation in excess of 1 pint within 56 days before dosing of medication
• •iron deficient
• •history or drug allergy of study medication
• •history of drug or alcohol abuse or dependency within the past 6 months
• •subjects cannot use any nicotine-containing products within the last 6 months
• •positive for HIV, Hepatitis B or C
• •active peptic ulcer disease
• •uncontrolled nausea and vomiting
• •active infection
• •heart failure
• •female who is lactating
• •female who has a positive pregnancy test