A Study Testing the Effect and Safety of Casopitant (GW679769) While Taking Warfarin in Healthy Human Volunteers

Exclusion Criteria

• •cannot participate if subject has a clinically relevant abnormality, medical condition, or circumstance that makes them unsuitable for the study per the study doctor.
• •blood donation in excess of 1 pint within 56 days before dosing of medication
• •iron deficiency
• •history of drug or alcohol abuse or dependency within the past 6 months
• •subjects cannot use any nicotine-containing products within the last 6 months
• •positive for HIV, Hepatitis B or C
• •use of prescription or non-prescription drug(s), herbal or dietary supplements or vitamins with 14 days prior to first dose of study medication
• •consumption of any food or drink containing grapefruit, Seville oranges, kumquats, pomelos (or their juices) within 7 days of the first dose of study medication
• •history of bleeding disorders or excessive bleeding
• •female who has a positive pregnancy test
• •female who is lactating