Phase I Trial of Paclitaxel With Perifosine

Inclusion Criteria

• •Histologically or cytologically confirmed diagnosis of cancer for which treatment with single agent paclitaxel would be an appropriate treatment option.
• •At least 18 years of age.
• •Patients can have received no more than two prior chemotherapy regimens for metastatic disease. Patients may be currently receiving paclitaxel using one of the schedules in the protocol, as long as the treating investigator has reasonable expectation that the patient will continue to receive paclitaxel for 2 or more additional cycles. The current regimen does not count towards the 2 regimens as long as the patient is not progressing on therapy.
• •Patients must have a life expectancy of more than 3 months.
• •Patients must have a performance status of 0 to 2 according to the ECOG criteria.
• •Patients must have normal organ and marrow function as defined below: leukocytes \>= 4,000/microL, absolute neutrophil count \>= 1,500/microL, platelets \>= 100,000/microL, HCT \> 28%, total bilirubin \< 2 x upper limit of normal, AST (SGOT)/ALT (SGPT) \<= 2.5 X institutional upper limit of normal, creatinine \<= 2.5 mg/dl transaminase \< 2.5 times institution's upper normal limits
• •Patients must have recovered from acute toxicity related to prior therapy, excluding alopecia, including surgery or radiotherapy.
• •Patients must be able to ingest oral medications.
• •Female patients who are pregnant or lactating are ineligible. All females of childbearing potential must have a negative serum pregnancy test within 72 hours of treatment. Men and women of childbearing potential must agree to employ adequate contraception to prevent pregnancy while on therapy and for four weeks after the completion of treatment.
• •Patients must have ability to understand and the willingness to sign a written informed consent document.