"Pecos" B-adrenergic and PPAR-G Stimulation Upregulates Lipid Metabolism in Human Subcutaneous Fat

Exclusion Criteria

• •significant renal, cardiac, liver, lung or neurological disease
• •high blood pressure
• •diabetes
• •prior use of thiazolidinedione
• •prior use of beta-blockers alcohol or drug abuse
• •history of thrombophlebitis, vascular or blood clotting disorders
• •unwilling or unable to abstain from caffeinated beverages and alcohol prior to adipose tissue biopsy and metabolic rates measurements
• •increased liver function test at baseline
• •have metal objects that would interfere with the measurement of the body composition
• •use drugs known to affect lipid metabolism, energy metabolism or body weight
• •use herbal supplements containing ephedrine and/or caffeine
• •take chronic medication, except hormone replacement or contraception
• •are a woman unwilling to use effective contraception during the trial
• •have heart disease or history of stroke
• •have urinary symptoms from enlarged prostate
• •have gained and or lost more than 10 pounds in the last 6 month
• •have use a monoamine oxidase inhibitor medication in the last month
• •have high or low thyroid function that has not been controlled in the normal range for at least 2 months