Prospective Randomized Evaluation Of Celecoxib Integrated Safety Vs Ibuprofen Or Naproxen

Exclusion Criteria

• •Subjects have had a recent cardiovascular event, unstable cardiovascular conditions, or any major surgery (cardiac or non-cardiac) within 3 months prior to randomization;
• •Subjects with medical or laboratory abnormality that would make the subject inappropriate for entry into this trial
• •Subjects require treatment with aspirin \> 325 mg /day
• •Subjects with known hypersensitivity to celecoxib, ibuprofen, naproxen, aspirin or esomeprazole, etc.