Stem Cell Study for Patients With Heart Failure

Inclusion Criteria

• •Subjects greater than 21 years old.
• •Subjects with functional class (NYHA) III ischemic heart failure.
• •Subjects who have attempted "best" cardiac medical therapy including long-acting nitrates, maximal use of beta-adrenergic blocking agents, and angiotensin-converting enzyme inhibitors without control of symptoms.
• •Subjects must be identified as non-candidates for conventional revascularization by their referring cardiologist. The patient's angiogram will then be reviewed by an independent interventional cardiologist and independent cardiac surgeon to determine if the patient is eligible for revascularization.
• •Subjects must have left ventricular ejection fraction \<40% by echocardiography.
• •All subjects must have a recent coronary angiogram (within the last 1 year) to document the coronary anatomy and insure the presence of coronary disease that is not amenable to standard revascularization procedures.
• •Have serum B-type Natriuretic Peptide (BNP) level \>100 pg/ml.