Personalized Environment and Genes Study

Study Description: The Personalized Environment and Genes Study (PEGS) integrates genetic and environmental data to understand disease etiology, identify disease risk factors, and improve disease prevention. Objectives: The objective of PEGS is to provide a resource for environmental health translational research by examining environment and gene-environment interactions in health and disease. PEGS will incorporate exposure and health information with or without genomic information to address the following objectives. * Primary Objective: To uncover novel environmental risk factors for the most prevalent health conditions and diseases. * Secondary Objective: To use an environmental precision medicine framework to uncover genetic susceptibilities to specific environmental exposures that can ultimately be used to provide a fuller understanding of individual risks for diseases. Endpoints: Primary Endpoints: 1. Dichotomous phenotype (multiple analyses; each analysis is focused on a single dichotomous phenotype of clinical interest, or a group of mechanistically related dichotomous phenotypes) Example: asthma; 2. Continuous phenotype (multiple analyses; each analysis is focused on a clinically relevant continuous phenotype). Example: FEV1, an indicator of asthma severity. Secondary Endpoints: 1. Phenome (simultaneous assessment of all clinically relevant phenotypes); 2. Exposome.